As sharing and secondary research use of biospecimens increases, IRBs and researchers face the challenge of protecting and respecting donors without comprehensive regulations addressing the human subject protection issues posed by biobanking. Variation in IRB biobanking policies about these issues has not been well documented.

This review should properly be prefaced with two caveats. First, I am not a specialist in the field of human origins. I am not an archaeologist or anthropologist, but a geologist who is generally unfamiliar with the literature covered and reviewed in this book as well as the issues and controversies. Second, I did not read the entire book. This review is based on a reading of the introduction and conclusion while skimming the rest of the text. For those who (...) find it unsettling that a reviewer has not read a book in its entirety, I can only tell you that it is very difficult to find people who are willing to donate the time necessary to read and review long technical books. (I’m still waiting on JSE to find reviewers for books I published in 2010). Anyone who is offended by my failure to peruse this volume from front to back covers may satisfy themselves with one-hundred percent of nothing by stopping their reading at this point. Ancient Ocean Crossings examines the evidence and arguments that human cultures in the Western Hemisphere were influenced by occasional contacts with ocean voyagers before Christopher Columbus arrived in the Americas in 1492. As the author notes, it’s now conceded that Vikings established a few settlements in North America hundreds of years before Columbus, yet these colonies were short-lived and apparently had little to no influence on American Indians. The ocean crossings referred to in the text are hypothetical voyages that may have occurred in the ten thousand years before Europeans first set foot in the Americas. There are some striking and unexplained cultural similarities between native peoples of the Old World and the Americas. These include “technical complexities of weaving and dyeing that are shared between southern Asia and the Central Andean region of South America, “stepped temple pyramids that are oriented to the cardinal directions in both Mesoamerica and Cambodia, and the belief “in both China and Mesoamerica, that raw jade can be discovered in nature owing to ‘exhalations’ coming from the stone” (p. 5). (shrink)

The EMERT(ecological microexpression recognition test) by Zhang, et.al.(2017) used block design for backgrounds, therefore participants could not get comparable scores. The current study used random design for backgrounds to improve EMERT to REMERT (random EMERT), and used eyes-closed and eyes-open resting-state fMRI to detect relevant brain activity of REMERT for the first time. The results showed: (1)Two new recapitulative indexes of REMERT/EMERT were adopted, such as microexpression M and microexpression SD. Using random design, the participants could effectively identify almost all (...) the microexpressions, and each microexpression type had significantly background effect. Using two EMERT as duplicates and calibrations, the REMERT had good duplicate reliability and calibration validity. Therefore the REMERT can be used as an individual test, and each participant can get comparable and recapitulative scores. (2)ALFFs in both eyes-closed and eyes-open resting-states and ALFFs-difference could predict microexpression M, and the ALFFs-difference was less predictive. The relevant brain areas of microexpression M were some frontal lobes, insula, cingulate cortex, hippocampus, amygdala, fusiform gyrus, parietal lobe, caudate nucleus, precuneus, thalamus, putamen, temporal lobe and cerebellum. (3)ALFFs in both eyes-closed and eyes-open resting-states and ALFFs-difference could predict microexpression SD, and the ALFFs-difference was more predictive. The relevant brain areas of microexpression SD were some frontal lobes, central anterior gyrus, supplementary motor area, insula, hippocampus, amygdala, cuneus, occipital lobe, fusiform gyrus, parietal lobe, caudate nucleus, pallidum, putamen, thalamus, temporal lobe and cerebellum. (4)There were many similarities and some differences of the relevant brain areas between microexpression M and SD. The ALFFs-difference was more sensitive to REMERT fluctuations. All these brain areas can be trained to enhance ecological microexpression recognition ability. (shrink)

In view of the confusion about the use of the term ‘population’ in biology, an analysis has been made of the use of the concept of population in biology. Origin and development, logic and epistemology of the population-concept have been investigated for that purpose. It appears that several concepts of population coexist in biology. The term ‘population’ is used for all these concepts, so it is not amazing that confusion has arisen. This confusion is the more dangerous, since ‘population’ plays (...) an important part in the theory of evolution. A modus has been suggested to diminish this confusion by defining ‘population’ in a very wide sense of the term and by proposing a ‘deme’—terminology to specify the various special concepts of population. (shrink)

This collection addresses a post-WWII shift in the hierarchy of scientific explanations, where the highest goal moves from reductionism towards some ...

Available evidence highlights the importance of emotion regulation in psychological well-being. However, translation of the beneficial effects of ER from laboratory to real-life remains scarce. Here, we present proof-of-principle evidence from a novel cognitive-emotional training intervention targeting the development of ER skills aimed at increasing resilience against emotional distress. This pilot intervention involved training military veterans over 5–8 weeks in applying two effective ER strategies [Focused Attention and Cognitive Reappraisal ] to scenarios presenting emotional conflicts. Training was preceded and followed (...) by neuropsychological, personality, and clinical assessments, and resting-state functional MRI data were also collected from a subsample of the participants. Results show enhanced executive function and psychological well-being following training, reflected in increased working memory, post-traumatic growth, and general self-efficacy. Brain imaging results showed evidence of diminished bottom-up influences from emotional and perceptual brain regions, along with evidence of normalized functional connectivity in the large-scale functional networks following training. The latter was reflected in increased connectivity among cognitive and emotion control regions and across regions of self-referential and control networks. Overall, our results provide proof-of-concept evidence that resilience and well-being can be learned through ER training, and that training-related improvements manifested in both behavioral change and neuroplasticity can translate into real-life benefits. (shrink)

This study first investigates robust iterative learning control issue for a class of two-dimensional linear discrete singular Fornasini–Marchesini systems under iteration-varying boundary states. Initially, using the singular value decomposition theory, an equivalent dynamical decomposition form of 2-D LDSFM is derived. A simple P-type ILC law is proposed such that the ILC tracking error can be driven into a residual range, the bound of which is relevant to the bound parameters of boundary states. Specially, while the boundary states of 2-D LDSFM (...) satisfy iteration-invariant boundary states, accurate tracking on 2-D desired surface trajectory can be accomplished by using 2-D linear inequality theory. In addition, extension to 2-D LDSFM without direct transmission from inputs to outputs is presented. A numerical example is used to illustrate the effectiveness and feasibility of the designed ILC law. (shrink)

For the theorists of crisis, the revolutionary state comes into existence through violence, and due to its inability to provide an authoritative katechon (restrainer) against internal and external violence, it perpetuates violence until it self-destructs. Writing during extreme economic depression and growing social and political violence, the crisis theorists––Joseph de Maistre, Juan Donoso Cortés, and Carl Schmitt––each sought to blame the chaos of their time upon the Janus-faced postrevolutionary ideals of liberalism and socialism by urging a return to pre-revolutionary moral (...) and religious values. They are united by three counterrevolutionary principles, all of which are purported to remedy revolutionary violence: traditional constitutional fidelity, the philosophy of the decision, and opposition to bourgeois liberalism. This essay is followed by the first complete English translation and publication of Donoso’s letter of October 24, 1851, which contains Donoso’s only reference to the “discussing class,” a political entity later popularized by Schmitt in his 1922 work Political Theology. (shrink)

Research targeting emotion’s impact on relational episodic memory has largely focused on spatial aspects, but less is known about emotion’s impact on memory for an event’s temporal associations. The present research investigated this topic. Participants viewed a series of interspersed negative and neutral images with instructions to create stories linking successive images. Later, participants performed a surprise memory test, which measured temporal associations between pairs of consecutive pictures where one picture was negative and one was neutral. Analyses focused on how (...) the order of negative and neutral images during encoding influenced retrieval accuracy. Converging results from a discovery study (N = 72) and pre-registered replication study (N = 150) revealed a “forward-favouring” effect of emotion in temporal memory encoding: Participants encoded associations between negative stimuli and subsequent neutral stimuli more strongly than associations between negative stimuli and preceding neutral stimuli. This finding may reflect a novel trade-off regarding emotion’s effects on memory and is relevant for understanding affective disorders, as key clinical symptoms can be conceptualised as maladaptive memory retrieval of temporal details. (shrink)

Abstract:The increasing needs for housing in Ghana is a result of urbanisation which is also a sign of improvement in the socio-economic lives of the people. Building of houses usually replaces prime vegetation land. The rate of indiscriminate devegetation for housing purpose in Ghana is as a result of the lack of a comprehensive land use policy implementation in the country. It is clearly stated in the country's land use policy that ‘the principle of optimum usage for all types of (...) land uses will be assured by the state and that, the state will ensure every socioeconomic activity is consistent with sound land use through sustainable land use planning in the long-term. But, evidence in the country is contrary to what is stipulated in the land use policy document. The study therefore, contributes to the environment-spatial land use conflict debate. It does this by focusing on the fast rate at which agricultural land at the fringes of urban Ghana is mainly used for housing purposes. It uses Accra and Tamale as examples to argue that if the content of the land use policy is not implemented to minimise the excessive devegetation for housing, the country stands the chance of losing utterly, its natural vegetation, especially, the forest vegetation. With the help of old maps, GIS and researchers’ observations, the study describes how the land use cover in areas close to the cities of Accra and Tamale has largely been replaced by housing. It ends by advocating sound sustainable housing typologies which will reduce the rate of devegetation in the country. (shrink)

Some theories of goodness are descriptively rich: they have much to say about what makes things good. Neo-Aristotelian accounts, for instance, detail the various features that make a human being, a dog, a bee good relative to facts about those forms of life. Famously, such theories of relative goodness tend to be comparatively poor: they have little or nothing to say about what makes one kind of being better than another kind. Other theories of goodness—those that take there to be (...) absolute goodness—are comparatively rich: they offer grounds for judging some types of things better than others because they have more absolute goodness. Moorean accounts, for example, can tell us that humans and human experiences are superior to bees and blades of grass. But such theories tend to be descriptively poor: they struggle to tell us in virtue of what this is so. In this essay we motivate and flesh out a view that splits the difference between accounts of goodness as relative and accounts of goodness as absolute. Such a view holds promise only if the mechanics of this kind of metaphysics of goodness can be worked out. Here we present a view on which the paradigm for absolute goodness is God and the paradigm for each kind of relative goodness is a divine idea. (shrink)

Since 1900, debates about the justification of punishment have also been debates about the cause of crime. In the early twentieth century, the rehabilitative ideal of punishment viewed mental illness and dysfunction in individuals as the cause of crime. Starting in the 1970s, retributivism identified the immorality of human agents as the source of crime, which dovetailed well with the “tough-on-crime” political milieu of the 1980s and 1990s that produced mass incarceration. After surveying these historical trends, Wirts argues for a (...) social critical view that crime is best understood as a product of an unjust society, not faulty human beings. This view should take the lessons learned by the critiques of rehabilitation, however, and resist the tendency to reduce human beings to recipients of social services. (shrink)

In 1979 astronomer Carl Sagan popularized the aphorism “extraordinary claims require extraordinary evidence”. But Sagan never defined the term “extraordinary.” Ambiguity in what constitutes “extraordinary” has led to misuse of the aphorism. ECREE is commonly invoked to discredit research dealing with scientific anomalies, and has even been rhetorically employed in attempts to raise doubts concerning mainstream scientific hypotheses that have substantive empirical support. The origin of ECREE lies in eighteenth-century Enlightenment criticisms of miracles. The most important of these was Hume’s (...) essay On Miracles. Hume precisely defined an extraordinary claim as one that is directly contradicted by a massive amount of existing evidence. For a claim to qualify as extraordinary there must exist overwhelming empirical data of the exact antithesis. Extraordinary evidence is not a separate category or type of evidence--it is an extraordinarily large number of observations. Claims that are merely novel or those which violate human consensus are not properly characterized as extraordinary. Science does not contemplate two types of evidence. The misuse of ECREE to suppress innovation and maintain orthodoxy should be avoided as it must inevitably retard the scientific goal of establishing reliable knowledge. (shrink)

Donald Davidson has made enormous contributions to the philosophy of action, epistemology, semantics and philosophy of mind and today is recognized as one of the most important analytical philosophers of the late twentieth century. _Donald Davidson: Truth, Meaning and Knowledge_ addresses * Davidson's writings on epistemology and theory of language with their implications of ontology and philosophy of mind * the central issue of whether truth is the ultimate goal of enquiry, challenged by contributions from Richard Rorty and Paul Horwich (...) * Davidson's approach to semantics and applied linguistics as addressed by Kirk Ludwig, Gabriel Segal, Peter Pagin, Stephen Neale, Herman Cappelen and Ernie Lepore and Reinaldo Elugardo * Davidson's advances in the philosophy of mind in relation to the views of Williard V. Quine, John McDowell and Peter F. Strawson, in essays by Roger Gibson and Anita Avramides. (shrink)

In July, the Department of Health and Human Services and the Office of Science and Technology Policy published an advance notice of proposed rulemaking proposing sweeping changes to the rules governing oversight of research on human subjects—changes aimed at “better protect[ing] human subjects who are involved in research, while facilitating valuable research and reducing burden, delay, and ambiguity for investigators.”1 The process is likely to amend not only the core regulation on human-subjects research , but also regulations governing vulnerable subjects, (...) IRB registration requirements, research regulations of the Food and Drug Administration, and the “privacy rule” of the .. (shrink)

Theological debate about the origin of evil derives from the quest after God’s goodness and justice. This problem can be constructively discussed only within the framework of a universe that has been created good, and within a corresponding anthropology. Anselm’s enquiry proceeds much along these tracks, and is based on the premises of the Platonic‐Augustinian view of evil as the privation of good, yet it concludes with a reference to the domain of the irrational and contradiction in which such a (...) discussion must necessarily harbour. The strength and uniqueness of his approach lies in his well defined hermeneutical and epistemological framework: his definition of theology as fides quaerens intellectum on the one hand, and his concept of ordo et pulchritudo universitatis on the other.The aim of this article is to discuss Anselm’s answer to the origin of evil in a wider context of his definitions of freedom and theology, trying to consider the issue, as Anselm does, from the point of view of the doctrine of Creation by the Word. His argument will be considered from the standpoint of Systematic Theology, which will enable us to contrast it with the thought of modern thinkers. Therefore the goal of this writing is not primarily to show how unique Anselm’s solution is in the history of dogma, but rather to highlight the uniqueness of the manner of his elaboration of this problem within his own theological framework. (shrink)

In Art of the Ordinary, Deming brings together the arts, philosophy, and psychology in new and compelling ways so as to offer generative, provocative insights into how we think and represent the world to others as well as to ourselves.

For decades, the dominance of the Clovis-first paradigm precluded the possibility of acknowledging a human presence in the Western Hemisphere before 11.5 ka. Yet there are a multitude of sites in the Americas with significant evidence for human occupation dating back to 200 ka and older. At two of these sites, Holloman in Oklahoma, and Hueyatlaco in Mexico, stone tools were found that indicate the possible presence of a lithic technology advanced beyond that found contemporaneously in Eurasia. Culturally modern humans (...) may not have originated in Africa as is currently thought, but in America where evolutionary change was facilitated by geographic isolation. Homo sapiens could have re-entered Eurasia from America as early as 75 ka and spread rapidly, displacing archaic Homo species. The opening and closing of the Bering Land Bridge over the last several hundred thousand years may have functioned as the pacemaker of human evolution. Keywords: Clovis, Out-of-Africa, evolution, Pleistocene, America. (shrink)

: Believing that philosophy had become a single-minded pursuit of a dead metaphor, Nietzsche constructs his authorial self as a "strong poet," a writer who attempts a new vocabulary and increases flexibility for available discourses. Building on observations by Gilles Deleuze, Sarah Kofman, and others, this article maps the literary register of Nietzsche's thinking, particularly in Beyond Good and Evil, to see the ways that tropes and rhetorical devices drive Nietzsche's textual negotiations. Such literary self-interrogation into how a text might (...) enact its own will to power gives rise—for Nietzsche, the reader, and for philosophy itself—to methods of self-overcoming. (shrink)

The topic of professionalism has dominated the content of major academic medicine publications during the past decade and continues to do so. The message of this current wave of professionalism is that medical educators need to be more attentive to the moral sensibilities of trainees, to their interpersonal and affective dimensions, and to their social conscience, all to the end of skilled, humanistic physicians. Urgent calls to address professionalism from such groups as the Association of American Medical Colleges, the American (...) Board of Internal Medicine, and the Accreditation Council for Graduate Medical Education, among others. In fact, at the 2004 annual meeting of the AAMC six separate presentations addressed professionalism with such titles as "Evaluating Humanism and Professionalism," Professionalism: Expectation, Education, Evaluation," or "Toward Assessing Professional Behaviors of Medical Students through Peer Observations". Professionalism, then, has become part of the current academic medicine parlance, used by administrators, clinical faculty, residency programs, and professional organizations with an expectation of shared meanings and goals. All of these stakeholders focus on what has become a consistent list of attributes deemed to be the essence of professionalism, which usually include variations on altruism, duty, excellence, honor and integrity, accountability, and respect. In fact, most of the scholarly work to date has been listing, describing, decrying, and measuring/evaluating it. In this collection of essays, we don’t argue with these attributes. Instead, we ask questions of the discourse from which they arise, how the specialized language of academic medicine disciplines has defined, organized, contained, and made seemingly immutable a group of attitudes, values, and behaviors subsumed under the label "professional" or "professionalism." This collection aims to be a critical text, one that questions the profession’s beliefs about the nature of its work and how such beliefs are enacted in medical education, particularly as they fuel the professionalism discourse. In addition, we will scrutinize how the discourse is enacted in both the formal and hidden curriculum, and in the larger medical environment. (shrink)